A leading national opinion maker and influential regional politician, tied by marriage to the families of Benjamin Franklin and cognate families, William Duane (1760-1835) played key roles in the field of political journalism, as well as national, Pennsylvania and local Philadelphia politics. Editor of the Aurora, William Duane (1760-1835) assured himself gratitude from Jefferson and the Republicans and enmity from President Adams and the Federalists for his open and effective attacks on Federalist policies. His son William John Duane (1780-1865), was a prominent member of the Pennsylvania legislature, a legal advisor to Stephen Girard, Solicitor for many of Philadelphia's premier institutions, and Secretary of the Treasury of the United States (June-September 1833). The Duane Family Collection contains a diverse assemblage of personal and professional correspondence relating to family members, with interesting material relating to William Duane (1760-1835), his son, William John Duane (1780-1865), grandson William Duane (1808-1882), great-grandson Charles Williams Duane (1837-1915), and other relations. The collection includes unique correspondence from and relating to Benjamin Franklin's family, as well as correspondence with Thomas Jefferson and other leading figures from the early nineteenth century. The collection also includes prints, photographs of family members, as well as some maps.

James Burd (1726-1793) was well-known in colonial Pennsylvania through his role in the French and Indian War, as well as his connections to many of the colony's leading families (most notably the Shippen family). Initially starting out as a merchant in Philadelphia, Burd became increasingly involved with colonial affairs after moving to Lancaster County with his family in 1752. It would be on the frontier where Burd would make his mark first as a soldier, and later as a magistrate. The Burd-Shippen Papers consist mainly of letters and business documents sent to James Burd, with the bulk of the collection relating to the French and Indian War, 1754-1763, in which Burd served as an officer commanding troops at Fort Augusta and elsewhere. The collection reflects all aspects of Burd's life in Pennsylvania as a merchant, soldier, and magistrate; as well as his involvement with the Shippen family professionally and personally. Intermixed with items sent to Burd are receipts to his wife Sarah Shippen Burd, and correspondence between Edward Shippen and James Hamilton regarding land matters and Indian affairs in Lancaster.

Nathanael Greene was one of the leading commanders in the Continental Army, and the only officer George Washington saw as capable of leading in his absence. Greene served as a field commander, member of Washington's staff, Quartermaster General, and commander of the Army in the Southern Theater. Greene was born on July 27, 1742 in Potowomut, Rhode Island to a Quaker family, who believed that their children would learn more from manual labor then from attending school. Lacking a formal education Greene was very intelligent and taught himself to read, developing early on a love of books - particularly military history and theory. It was through reading, not experience, where Greene learned his knowledge of military science. Between 1778 and 1780 he reluctantly served as Quartermaster General, and was able to drastically improve supplying the Continental Army. Greene ended his military career leading the American Southern army to victory over the British. Greene died in Georgia in June 1786. The Papers of Nathanael Greene come from Greene's tenure as Quartermaster General of the Continental Army between 1778 and 1780. The collection primarily consists of Greene's correspondence with officers in the quartermaster department, officers in the Army (including George Washington), and members of the Continental Congress; relating to the operation of the Quartermaster Department with requests for supplies, forage, and money. In addition, there is also correspondence between officers of the Quartermaster Department. The content of the letters provide a detailed account of the logistical obstacles that Greene and his subordinates faced in trying to keep not only the Quartermaster Department but the Continental Army running. The papers do not contain any material relating to Greene's military service or private life either before or after his tenure as quartermaster general.